Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer
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چکیده
منابع مشابه
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There has been little study of how the evolution of chemoresistance in cancer affects other aspects of disease pathogenesis. Here, we show that an important chemoresistance axis driven by cytidine deaminase (CDA) also acts to suppress cell-cycle progression by regulating cyclin E-CDK2 signaling. We found that CDA was regulated by miR-484 in a gemcitabine-resistant model of breast cancer. Elevat...
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miRNAs (miR) are a critical class of small (21-25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast cancer growth. Nischarin (NISCH) expression was augmented by knockdown of miR-23b...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2018
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-17-0634